Briefly, at the correct developmental time point, the synchronized worms were washed in M9 and sucrose floated.
However, differences between control and treated groups were less important on days 4 to 7, when the therapy had been withdrawn, and there was still no difference between uncorrected and corrected data at these time points.
For dichotomous outcomes, we used logistic link generalised linear mixed models for repeated measurements to analyse differences within and between groups at all time points, correcting for the same covariates.
Linear correlations were evaluated by Pearson's R. To correct for correlations calculated at multiple time points, correlations with p-values < 0.01 were considered significant.
The transcriptome of a cell is tightly regulated by epigenetic mechanisms to allow correct gene expression patterns at appropriate time points.
SUR and SUV measured at the respective reference time were used as the 'gold standard' against which the corrected uptake values acquired at further time points were compared.
One-tailed paired t tests were performed to compare treatment areas under the curve, and a doubly repeated-measures analysis of variance was performed to compare treatment responses at individual time points (P<.05, Bonferroni corrected).
Schizophrenia patients showed fewer correct responses compared to healthy controls at both time points.
Weight and body composition (percentage fat, skeletal muscle mass) were measured at all time points using BIA Omron HBR-500 Body Composition Monitor with Scales correct to 0.1 kg.
Time was defined as the exact number of months between the baseline and each visit, thus using all data points at the correct time intervals.
