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Peritumoral vascular invasion at central pathology review.
At central pathology review, over half (53%) of the locally diagnosed AA cases could not be confirmed.
The current study was carried out in the Efficacy Population, which was formed when 3 patients who did not provide informed consent were excluded, as well as 15 patients who did not have GIST at central pathology review, and 24 patients who had 1 or more metastases removed in addition to the primary tumor at surgery.
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Furthermore, at the central pathology review nine patients were considered as not having primary ovarian cancer but instead six cases with metastatic disease from another primary tumour and three cases with borderline ovarian tumours.
Interestingly, in our study, the proliferation-related biomarker, Ki-67 by IHC, did not predict paclitaxel benefit despite being evaluated at a central pathology laboratory, while the 11-gene proliferation score was significant.
At the onset of a spinal lesion 5.5 years later, both tumors were pathologically and molecularly evaluated at the national central pathology review board and defined as ATRT in a syndromic patient, with strong evidence of a clonal origin of the two lesions.
In addition, we could not adjust for the number and experience of surgeons and pathologists at each institution; no central pathology review was performed, possibly leading to differences in patients' treatment strategies.
Tissue microarray, (TMA) data from central pathology review at St . Bartholomews Hospital, London has been performed on 1336 randomly selected tumour samples.
Moreover, despite the central pathology review at study entry confirming the oligodendroglial nature of the tumor (and thus all cases were diagnosed as oligodendroglioma by two pathologists), the reviewers that took part in the second review still diagnosed some tumors as AA or GBM.
Liver allograft biopsies (confirmed by a central pathology laboratory) were obtained at baseline and at 12 months to assess histology.
All cases underwent central pathology review by at least one specialist pancreatic histopathologist (AJG, AC, JGK) who was blinded to the diagnosis and clinical outcomes to verify the diagnosis of pancreatic ductal adenocarcinoma and to define histopathologic features in a standardized manner using a synoptic report developed for the purpose (Gill et al, 2009).
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