Concerns regarding beam-induced sample alterations arise if it is attempted to understand structure and chemical composition of materials at atomic resolution with single atom sensitivity.
Single atoms can also be detected at atomic resolution by collecting secondary electrons (SE) [33].
However, to obtain information at atomic resolution, NMR resonances first have to be assigned to their corresponding atoms in the protein.
NMR ideally probes both types of dynamic exchange at atomic resolution.
Thus, data at atomic resolution of the type provided by NMR and EPR are invaluable.
With no other changes, off-axis holography could be performed at atomic resolution.
The early stages of peptide aggregation are currently not accessible by experimental techniques at atomic resolution.
Structure-based design studies suffer from the lack of available protein structures at atomic resolution.
In combination with structure prediction program Rosetta, we modeled Aβ42 fibril structure at atomic resolution.
The øX174 procapsid was the first such assembly intermediate to be solved at atomic resolution.
Characterizing the influence of these effects requires a technique capable of measuring structural information at atomic resolution.
