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In any study of this type, brains donated at death represent a cross-section of the cohort at a specific terminal point.
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Here we report that palmitoylation of LIMK1 at a specific N-terminal motif is necessary and sufficient to target LIMK1 to spines.
Caspase-3 has been found to cleave excitatory amino-acid transporter-2 (EatT2) at a specific cytosolic c-terminal site resulting in the selective inhibition of this transporter hence playing a crucial role in the pathogenesis of ALS [ 19].
The primary known function of CSK is to phosphorylate c-Src at a specific tyrosine residue in the C-terminal tail and thereby inactivate c-Src.
They all cleave fibrillar collagens at a specific site, resulting in the generation of N-terminal 3/4 and C-terminal 1/4 fragments, which are further degraded by gelatinases [ 7, 9, 10].
Greider, C. W. & Blackburn, E. H. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts.
Interestingly, a specific N-terminal hnRNP K fragment that migrates at 48 kD accumulates during erythroid differentiation.
Bioinformatic analysis identified Tn 3-specific terminal repeats (Siguier et al. 2006) in pPDL2: two at the terminal ends of Tn 3 and a third at the upstream region of transposon y4qE.
A specific site at the N-terminal of Sx 1A bound at N773 859, was shown to be responsible for Cav2.2 function [21].
Bidimensional NMR experiments indicate that a specific site at the N-terminal α-syn (Gly31/Lys32) is involved in the interaction with vitamins K, which is corroborated by previous studies suggesting that Lys is a key residue in the interaction with quinones.
This suggestion is then bolstered by the observations of DNA binding at the geminate interface, with a specific interaction between R41, at the extreme N-terminal end of the helix-turn-helix motif, and the DNA backbone of nucleotide 5.
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