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However, the causal gene and variant at a specific linkage disequilibrium block is often unclear.
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Subgroups were chosen with at least a polymorphism mapping to a specific linkage region of the map of Taenzler et al. (2002).
There were no marker inconsistencies at linkage group level (that is, no marker was present on a specific linkage group on one map and present on another linkage group on the other map).
How does a specific DUB recognise a specific linkage type?
However, we did assign each of these markers to a specific linkage group.
For eQTL, the permutation was performed 10 times, and the average number of transcripts showing linkage at a specific LOD score was used to calculate FDR.
For eQTLs, the permutation was performed 20 times, and the average number of transcripts showing linkage at a specific LOD score threshold was used to calculate FDR.
Genetic association testing can then be carried out in the narrowed region using the population of inbred lines to identify the gene or genes that at least partially explain the specific linkage to disease.
DOI: http://dx.doi.org/10.7554/eLife.03083.014 Regulation of APC in mitosis employs a special E2 enzyme, Ube2S, which elongates ubiquitin chains on a substrate through specific linkages at the K-11 position of ubiquitin (Williamson et al., 2009; Wu et al., 2010).
Gender-specific effects were also observed, with a male-specific linkage peak at 8p and female-specific ones at 15q and the 19q APOE locus (Beekman et al. 2013).
Sutter, N. B., Eberle, M., H. G., P., Kruglyak, L. & E. A., O. Extensive and breed specific linkage disequilibrium in Canis familiaris.
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