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Each assay was carried out in duplicate at a single compound concentration (22 μM).
The profiling of BI2536 and TG101209 against a panel of 32 BRDs was performed by Discoverx Corp. at a single compound concentration of 2 μM.
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In September 2012, the US Centers for Disease Control and Prevention CDCC), in collaboration with state and local health departments, initiated a multistate investigation into an outbreak of fungal infections linked to injections of preservative-free methylprednisolone acetate (MPA) produced at a single compounding pharmacy (New England Compounding Center [NECC], Framingham, MA, USA) (1, 2 ).
We improve the reference prediction (a) by modifying the predicted probability of a single compound at different positions in the ranking: in (b d), a single active compound is predicted with higher probability and shifted 4 positions upwards in the ranking.
However, predictions were limited to a single compound at a specific age, and such data-based models might not be applicable to other ranges of exposure and populations because of genetic and life habit differences.
To our knowledge, it has never been unequivocally shown for any of these compounds that ETC inhibition is instrumental in cell death induction by correlating ETC inhibitory efficacy of a single compound at any of the ETC complexes with the extent of cell death.
All the abovementioned methods focus on a single compound or at most in combination with metabolites when an in vivo system is in use, and idealistic (or non-realistic) conditions which are not complimentary with the real life situation where the drug of interest is used.
Adverse responses after ambient exposures to complex mixtures often occur at concentrations below those producing effects in controlled human exposures to a single compound.
These nine electrodes can be applied conveniently using a single compound electrode sticker, in which all electrodes are at their correct relative positions with respect to each other.
Figure 4 represents only a single compound alignment case, where the vertical vertex is positioned at station 3200.
Beginning at day 1 of adulthood, animals in each well were exposed continuously to a single compound or to the vehicle control (0.33% DMSO).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com