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Different methods are then compared at a same cutoff.
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At a same rank cutoff, the structural scores of interactions inferred by BINM are consistently higher than the scores of interactions inferred by the three compared methods (except the top 1,500 predictions on the Friedel dataset).
It is noticeable that the physical interactions identified by BINM, MST and eMST can sufficiently connect more complexes than those identified by AP-MS at a same rank cutoff.
Each round consisted in: 1) a 3-step DQing process starting at the same cutoff of the previous assembly and then decreasing the cutoff by 105 at every successive step and 2) an automatic end-joining step performed increasing the cutoff value of the previous assembly by 105 times.
In comparison, our study established a lower sensitivity for the PHQ-2 at the same cutoff score.
If it is used for a case-finding approach limiting to noncritical care settings, then at the same cutoff value, two-thirds (sensitivity 69%) of the admissions with adverse outcomes could potentially be identified.
Percentages of correct predictions of mortality were obtained at these same cutoff points.
In contrast, only 3.5% of the 285 less conserved essential genes were identified by SC_GenProt at the same cutoff.
At the same cutoff in the NHTBE cells, 8% of genes detected using IVT were not detected using dIVT.
We were also able to detect many more modules at the same cutoff levels, suggesting greater network resolution.
We found that 71% of these regions contained at least one SBE at the same cutoff used for scanning the target regions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com