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The noise was applied at a proximal site, on a defined region of the tibial nerve path above the ankle.
More than a century of study has strived to discover the nature of these large-scale movements at a proximal level [reviewed in 2], [3].
For instance, when the electrode was at a proximal position –close to the axon terminal- we could see a fast depolarizing transient similar to the ones reported to occur in fly photoreceptor axons [76] (arrow in Fig. 4B).
The reduction in response to GPVI can be accounted for by a decrease in tyrosine phosphorylation at a proximal stage of its signalling cascade, as phosphorylation of the FcRγ-chain and Syk are reduced.
The FcRγ-chain runs as a distinct band in the whole cell lysate and, importantly, its phosphorylation can be seen to be reduced revealing that inhibition occurs at a proximal stage in the signalling cascade.
We have previously shown that V. cholerae CPD is positioned to undergo autocleavage at a proximal N-terminal leucine and that it exhibits significantly reduced transcleavage efficiency [4], [5], which should limit its ability to cleave target proteins at heterologous sites.
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Penetration was defined to begin at the base of a proximal penetration sprout, and to end at the most distal point of cement along a radial test line.
Results also show that relative cost for carrying a mass at a distal versus a proximal location changes with speed and mass.
The predictive algorithm was developed using a simplified model comprising of a CORA at the intersection of a proximal anatomical axis and a distal anatomical axis.
Further, while cells expressing Jak2V617F had constitutive activation of STAT5, cells expressing Jak2V617F/Y114A did not, suggesting that signaling is defective at a very proximal level.
Usually, the 3rd wire is taken at a more proximal or distal level to enhance stability.
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