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ELSO guidelines suggest to keep Hb at a normal value 12-144 g/dl) and frequently 2-3 PRBC units are transfused daily, but also in this setting have been reported lower Hb trigger for transfusion.
The fact that a large tidal volume, previously proposed to maintain arterial carbon dioxide tension at a normal value, is no longer used today may explain the improvement in ARDS prognosis observed over the past two decades [ 7].
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The second patient (case 2) who had slightly increased bilirubin at 3 months but a normal value at 1 year had HEF increased from 42% to 100% after conversion.
Blood glucose level was kept constant by titrating an insulin infusion, ventilation was adjusted to maintain arterial PCO2 at 50 mmHg, a normal value for our animal model.
The platelet count started to increase at 3 8 days after the start of treatment in seven patients, reaching a normal value at 16 28 days.
In wild-type mice, the SFI decreased to a minimum 3 days post-operation and then progressively recovered to reach a normal value at day 15.
Three patients experienced a shift in CPK elevation with a normal value at baseline to >10 × ULN post-baseline.
Among patients studied, 121 (84%) experienced at least one plasma hs-cTnT of more than 15 ng/L and only 7 (6%) had a normal value at admission.
One participant was excluded after the first intervention because of having abnormally high fasting blood glucose concentrations (despite having a normal value at screening) and one further participant withdrew during the second intervention because of illness (abdominal discomfort).
Although PCT levels were elevated at the time of enrolment (above a normal value of 0.3 ng/mL) in all groups, the maximum PCT occurred a median of 1 to 2 days after inclusion in the study.
Three patients had a normal value for audiometric examination at baseline, but an abnormal evaluation at a later examination.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com