So, the specificity of a developmental stage determines how likely it is for regulatory genes of that stage to cause a state transition of the genes at the next stage; a higher specificity decreases that likelihood.
Decision rules with a higher specificity at the cost of missing fractures were considered unsuitable.
For the same cut-off (i.e. SBST cut-off ≥ 4), the present study showed a lower sensitivity but a higher specificity at both short- (66.7 and 77.5 %) and long- (75.0 and 72.1 %) terms.
However, as the urine-based metabolomic diagnostic test for colonic adenomatous polyps is a quantitative one, the model cutoff value can be transformed to generate a higher specificity at the expense of the sensitivity.
Improvements in sensitivity have been proposed by introducing other tests, such as immunochemical faecal tests, 17 18 19 with the potential for a higher specificity at the same analytical threshold as the guaiac based test used in Finland.
Taken together, our data suggests that in populations such as ours, where the overall incidence of breast and ovarian cancers is lower than that in Caucasian populations, family history is more significant therefore giving a higher specificity at a lower score.
This masking causes delay in generating an alarm and the delay is more pronounced at lower case reporting rates and a higher specificity and is, for example, responsible for reducing the method's sensitivity to 98% at α = 0.5% and Sp = 99%.
In their 1990 histopathological study, van den Brekel et al. found that, when combined with minimum axial diameter, the presence of groups of three or more nodes of borderline size at appropriate drainage sites increased sensitivity at a high specificity[ 32 ].
