The phrase "at a high specificity" is correct and usable in written English.
It can be used in contexts where you want to describe something that is very precise or detailed, often in scientific or technical discussions.
Example: "The test was designed to identify the disease at a high specificity, ensuring that false positives were minimized."
Alternatives: "with high precision" or "at a detailed level".
Increasing the sensitivity at a high specificity level for ACPA detection appears difficult to achieve.
In their 1990 histopathological study, van den Brekel et al. found that, when combined with minimum axial diameter, the presence of groups of three or more nodes of borderline size at appropriate drainage sites increased sensitivity at a high specificity[ 32 ].
DNA methylation in the SHOX2 locus was previously used to reliably detect lung cancer in a group of critical controls, including 'cytologically negative' samples with no visible tumor cell content, at a high specificity based on the analysis of bronchial lavage samples.
SHOX2 DNA methylation, operating as a biomarker at a high specificity and sensitivity in a group of lung cancer patients and critical controls based on the analysis of bronchial lavage samples, has recently been proven to be a suitable means for diagnosing lung cancer [ 14].
This work introduces a new method for rhythm analysis during CPR with a novel design approach aimed at obtaining a high specificity.
IFA positivity for Babesia spp. IgG antibody at >1 64 has a high specificity (90%100%%) (14 ), but its predictive value is uncertain because disease prevalence is unknown for healthy blood donors.
It cannot distinguish between curves with a high sensitivity at moderate values of the specificity and curves with a high specificity at moderate values of the sensitivity.
Combined analysis of the miRNAs and cytology presents a higher sensitivity compared with a single approach, maintaining a high specificity at 93.0%.
The use of USPIOs improves the sensitivity of MRI (using standard size criteria of nodes) from 29% to 82-93%, whilst maintaining a high specificity at 97%[46]].
KLAS and ANOSVA displayed relatively good results whereas the remaining three methods showed either a high specificity at the cost of sensitivity (MADS') or a high sensitivity with a sacrifice of specificity (SplicingCompass, PAC), see Additional file 2: Figure S6.
Using quantitative detection and Nugent scoring as the gold standard for BV, the combination of Prevotella spp. and A. vaginae had a high specificity at 99%, but the sensitivity decreased to 90%.
