Since the true alignment tends to have a high alignment score, it is possible to prune low-scoring matches at each node, and consequently restrict dynamic programming around good matches only.
In the experiment of Fig. 2c, at a high structural alignment ratio cutoff, only those DSCO pairs with small swapped domains and common homologous pairs with a small number of non-superimposable residues were eliminated.
Once benchmarks of sufficient resolution at high alignment accuracy levels become available, it may be interesting to investigate whether improving the POA based stage in SINA with methods used by de novo MSA tools such as Infernal, MUSCLE or MaFFT can further enhance alignment accuracy.
While good alignment and consistency are obtained for statistics and invariants at a high Karlovitz number, both alignment and consistency degrade at a low Karlovitz number.
The MA6 is equipped with a motorized Topside Alignment System providing a high precision alignment accuracy of ± 0.5 μm.
Cases where the EST evidence supported only one of the NAG acceptors were called constitutive, whereas cases with EST support for both acceptors were called alternative (here EST support means at least one EST from a high quality alignment, as described in the section "Methods").
The number or signal intensity of glial cells stained by anti-repo antibody were reduced and photoreceptor cells stained by anti-elav antibody showed abnormal alignment and morphology at a high magnification in the retina of the repo; hHtt103Q flies (Fig. 3B).
Although the respondents generally believed that there is alignment of priorities at a high level, some noted that organizational sub-units set priorities based on their own local needs.
The graphitization degree of modified foam reached 84.9% and the ligament of graphite foam exhibited high alignment after carbonization at 1200 °C for 3 h and graphitization at 3000 °C for 10 min.
All known and uncharacterized gene reads of Roche 454 were assembled at a higher stringency (95% of alignment identity) using gsAssembler (Roche Applied Science) (batch_gsassembly.pl, Table S1 in Additional file 1).
