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If the simulation includes use of mitigation interventions, these begin immediately at a predefined number of incident cases (10, 30, or 100), are carried out by the community with a specified level of compliance (60% or 90%), and end at a defined threshold of number of new cases in a 7 day period (0 or 3).
We expected to see a clear distinction between non-responding and responding cells at a defined threshold level of DSBs.
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The cycle at which fluorescence exceeded a defined threshold (CT score) in this analysis varied widely for Wnt ligands with most being barely detected (i.e. CT score greater than 30).
The ICER can be used to help define an acceptable "value-based" price range for the new intervention, with the maximum acceptable price being the price at which the ICER crosses a defined threshold [ 2].
Low OPTN expression was defined as expression below a defined threshold at which the significance (P-value) of the standard deviation and fold change of OPTN expression in each CD patient when compared to mean expression in HC was P<0.005 and 1 on the log2 scale, respectively (Smith et al., 2015).
When the observed log2-FC at these points was higher than a defined threshold the probe was included for further analysis.
At any defined threshold, each of these pairwise alignments extends through a discrete local region in both query and target sequence and, together, these regions cover the query sequence to a greater or lesser extent.
The cycle number at which a sample crossed a manually defined threshold (called the C t value) is therefore indirectly proportional to the amount of template.
The concentrations of these three biomarkers were then correlated with all individual proteins measured by MS, and those with significant correlations at the defined threshold (p ≤ 0.05 and r ≥ 0.3 or ≤ -0.3) were selected for further analysis.
Because of the sheer number of assessed interventions, it was practicable only to show graphically probabilistic uncertainty estimates for interventions that are less costly or more effective than other less efficient interventions, thereby omitting other interventions with a lower but still real probability of being cost effective at defined threshold levels.
At primary diagnosis, each 17 (68.0%) cervical and endometrial cancer, 6 (26.1%) ovarian cancer and 8 (38.1%) breast cancer patients over-expressed at least one out of the 93 potential candidate genes at levels above the defined threshold.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com