Sentence examples for at a defined site from inspiring English sources
The TFO binds a unique sequence on the pTUC plasmid that allows us to position the psoralen moiety at a defined site between two AT base pairs as shown on Figure 1B.
Each step has been studied in vitro using cell extracts or highly purified repair factors and radiolabeled DNA of known sequence with DNA damage at a defined site.
The multi-copy insertion of transcriptional reporter constructs into single genomic sites in mammalian cells provides the signal intensity needed to investigate transcriptional dynamics at a defined site.
These mice develop intimal lesions within 2 weeks at a defined site of the arterial tree, making it an attractive model for drug screening (Lardenoye et al, 2000).
These findings suggest that genome remodeling starts at a defined site in the genome and spreads in a spatially regulated manner, ending up with the nuclear compaction found universally in male gametes.
In this approach, the 3D structure of a wild-type protein is used as a template for modeling protein mutants with amino acid residue substitutions (deletions, insertions) at a defined site, typically at the binding site of the protein.
The accurate assessment of the potential wind energy at a define site is very important from economic point of view, measures cost effectiveness of the project and helps estimating future incomes, revenues.
One prediction of this hypothesis is that the disintegration reaction could demonstrate some sequence preference if integration, which must happen at a specific, defined site in the CRISPR locus, is partly driven by the sequence specificity of Cas1.
The results indicated that DSBs triggering deletions in lymphoid leukemia are formed at a few defined sites by illegitimate action of the RAG protein complex, while DSBs in solid tumors are formed at unspecific sites by factors unidentified yet.
Double strand breaks (DSBs) triggering 9p21 deletions in ALL have been reported to occur at a few defined sites by illegitimate action of the V(D J recombination activating protein complex.
46– 50 This indicates not only successful POM binding but that the interaction can only take place at a conformational strongly defined site, which was suggested to be subdomain IIA.
