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Male and female Mlh1 −/− and Mlh1 +/+ mice were irradiated with 2 Gy X-rays when aged 2 weeks or 7 weeks and/or were treated with 1% dextran sodium sulfate (DSS) in drinking water for 7 days at 10 weeks old to induce mild inflammatory colitis.
The risk of fetal loss before 20 weeks gestation given the pregnancy was terminated at X weeks gestation is estimated by the probability of fetal loss at X weeks divided by the probability of fetal loss at 20 weeks gestation.
Make sure the puppy is at least 10 weeks old, but no older than 6 months.
Morphometric analysis was carried out at P45. 3) Tolerance study: Rosa26 rtTA/+ ;tet(O Fgf10 and WT mice (both 10 weeks old) were exposed to doxycycline for 2 weeks.
All the nestlings were sampled at about three weeks old.
In females, compared with DSS treatment alone, combined exposure to X-rays at 2 weeks old also increased the number of high-grade adenomas and hyperplasia.
In contrast, the failure to observe an enhanced incidence of colon lesions in females with combined exposure to DSS and X-rays at 7 weeks old was due to an unexplained decrease in low- and high-grade adenomas and carcinomas.
A single colon lesion was observed in an untreated male and one in a female exposed to X-rays at 2 weeks old, an indication of the low baseline frequency without DSS induction.
Although BW was significantly lower in all treated male mice on the Mlh1 −/− background compared to treatment-matched WT males, only the combined exposures and X-rays at 2 weeks old caused a significant reduction below the weight of the Mlh1 −/− control males (Table 1).
In females, both DSS alone and in combination with X-ray irradiation at 2 weeks old significantly increased incidence above that observed in untreated females, with a higher frequency when the DSS followed irradiation at 2 weeks old.
RNA-Seq libraries were prepared from a male Large White x Landrace pig (about 7 weeks old).
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