The average leakage current under negative formation (NF) is 229.7 pA at a read voltage (Vread) of -2.0 V, while it is 673.3 pA under PF at a Vread of +2.0 V. Asymmetry values of the leakage currents under NF and PF polarities are quite reasonable due to the different work function (Φm) values of IrOx [ Φm IrOx ≈ 5.2 eV [14], and of W [ Φm)W ≈ 4.3-4.91 eV [29]] electrodes.
This was done for both the variation among individuals (means of both sides for size and shape) as well as for FA (signed asymmetry values of size and shape).
Sequence asymmetry values of dinucleotide counts surrounding a representative TSS: The respective numbers of dinucleotide content (AA or TT denoted by AA_TT, CC or GG by CC_GG) and single nucleotide content (A, C, G, T, A or T represented by A_T, C or G by C_T) were counted 500 bp upstream and downstream of each representative TSS.
The median, 97.5th percentile, and 99.5th percentile of the asymmetry value of the VCDR were 0.05, 0.17, and 0.24, respectively.
The 97.5th and 99.5th percentiles of the VCDR on the left or right eye and those for the asymmetry value of the VCDR were used as the cutoff value for category 1 and category 2 glaucoma diagnoses, respectively.
The significance of asymmetry values for each pattern was analyzed using raw data (Student's t tests of the mean relative to 0).
Using the L ker, PAM, r values, the above stated allows us to roughly determine the range of asymmetry values c at which the quality of global alignment decreases.
With each representative TSS, we tested associations of a set of parameters: gene expression level (in log scale), breadth of the TSS, mononucleotide counts and mononucleotide asymmetry values upstream and downstream of the TSS, and periodicity and consistency of nucleosome positioning upstream and downstream of the TSS (see details in Methods).
The Jamrar subwatershed show strong asymmetry (average is 0.496) while the low topography asymmetry values (average is 0.17) of Baragl subwatershed explained by less tilt of the basin.
This would in turn result in a leptokurtic distribution of asymmetry values, which appears to be widespread as well [ 13, 16].
Spearman's rank correlation coefficient matrix for dinucleotide content (AA or TT denoted by AA_TT, CC or GG by CC_GG), single nucleotide content (A, C, G, T, A or T represented by A_T, C or G by C_G), and their asymmetry values (Sa) upstream and downstream of TSSs in the Hd-rR (Hd) and HNI (HN) strains.
