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In total, 1,938 children at risk of asthma were selected from general practice and 771 children (40%) were enrolled.
In this prospective cohort study one to five year old children at risk of developing asthma were selected from general practices.
In three areas in The Netherlands, one to five year old children at risk to develop asthma were selected from 14 general practices.
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Children with asthma were selected based on established pediatric diagnosis and medications taken.
Asthma (n=514) and control (n=104) subjects were selected from 200 families and 407 trios, both ascertained through an asthmatic proband and characterized using a standardized study protocol, with asthma from the northern part of the Netherlands and studies with an identical protocol, as described previously (26).
Asthmatic subjects matched to normal controls in terms of age, sex, and body mass index (BMI) were selected from among the asthma cohort of Bucheon Hospital for inclusion in this study.
Constructs were selected from previously published ED studies of short-term outcomes and HRQOL, including prior assessments of fever [ 16], and acute asthma[ 17, 18].
They were selected from 11 semi-finalists.
The reference group was selected from a population-based study on asthma and chronic rhinosinusitis.
Pharmacist participants will be selected from different regions throughout the country to reduce potential impact from North South climatic variation, which could impact asthma severity.
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