When caregiver costs were excluded from our analyses, ranibizumab treatment was cost-saving at 10-years under only one set of assumptions: sustained-effectiveness, administration of ranibizumab less frequently for only 2 years, and the ranibizumab cost equal to the bevacizumab price (Table 6).
These results contrast some assumptions of sustained reactive inhibition models.
This assumption was sustained by impedance measurements.
Our model-based analysis suggests that SPG stimulation for the treatment of chronic cluster headache, under the assumption of sustained therapy effectiveness, leads to meaningful gains in health-related quality of life and is a cost-effective treatment strategy in the German healthcare system.
This assumption is sustained by recent works, in which it has been demonstrated that ω-3 PUFAs are able to counteract the Warburg effect.
For scales involving polytomous items as the EPDS, by definition, the m = 3 item step response functions (ISRF) of any given item containing m+1 = 4 levels may not intersect if the monotonicity assumption is sustained [ 48].
This assumption is sustained by the high prevalence of certain neoplasia (lung, colorectal, or gastric) occurring at the age of 40 to 50 years (similar to the onset age of MN) and by the high prevalence of HBV infection in certain geographic regions [ 37].
Only then, we might step out of the maze of clinical and therapeutic assumptions that sustain a prominent role for CSD in human neuropathology.
This way of stating the lesson, however, appears to leave open the possibility that certain philosophical problems eventually may legitimately be taken seriously that is, at face value in the sense that they require constructive solutions provided the assumptions which sustain their formulation stand up to proper critical scrutiny.
Although the assumptions of the sustained arousal model cannot be proved per se, it allows for deduction of testable hypotheses.
By assumption, unions sustain an exogenous per member (symmetric) transaction cost (tau ge 0) for the coordination of activities.
