The assumption of 100% specificity amounts to an assumption that punch biopsy yields pathognomonic results.
Although the assumption of 100% specificity for punch biopsy is only approximately true, it could be justified from a clinical perspective in that there is more concern with HRA sampling error (reducing biopsy sensitivity) than with false positive biopsy results.
The second assumption of perfect specificity implies that adequate information is available for each eligible case of AFP identified to resolve potential false positive results and allow a definitive diagnosis to be made.
The assumption of perfect specificity is supported by WHO surveillance standards [ 12] which require a minimum rate of AFP case notification and stool sampling, the timely and complete collection of clinical information, follow-up assessment for a minimum of 80% of cases, and the use of accredited laboratories and an expert review committee.
A substantial body of theoretical and empirical coevolutionary work is based on either the implicit or explicit assumption of high specificity in host-parasite interactions, which should "ideally" lead to negative frequency-dependent selection and spatio-temporal adaptation of antagonists [ 20, 43, 44].
SCIMM-Search can be used to automatically generate informative probe sets in circumstances where the specificity assumptions of SCIMM may not be satisfied for all probes in the putatively deleted region.
Thus, in line with other authors, we demonstrated that falls prevention programs have a positive impact on EF [ 111], however, the findings also support the assumption that specificity of training applies to these specific EFs.
However, to demonstrate the extent to which we have "stacked the deck" in favor of blood donor screening, we relax the assumption of perfect test specificity for noncontagious agents.
4. The assumption of perfect viral specificity is unlikely to be possible and it is therefore important to quantify the cost of tumor therapy in terms of the reduction in the healthy population of cells in relation to the reduction in cancerous cells.
For this reason, designing a placebo in complementary and alternative medicine research is often dependent on unsubstantiated assumptions about the specificity of the intervention [ 99].
