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Fig. 5 Visual illustration of the three assumptions of evolution by natural selection.
Yamanoi (2008) reported that even after the origami bird experiment with the original protocol, Japanese high school students who had studied evolutionary concepts failed to understand the three assumptions of evolution by natural selection.
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Since intra-patient recombination would lead to the creation of mosaic genomes violating the tree-like assumption of evolution, we carefully checked for recombinant sequences within our data sets before performing high-resolution phylogenetic analysis.
Ultimately, all diagnostic tests of our correlation analyses were insignificant, indicating our data met the assumption of evolution under a Brownian model.
We think that the number of the members of the respective subgroups, the distribution of Q2-2 and Q2-3 as well as the distribution of non-finger conserved motifs favor the assumption of evolution from a low number to a higher number of domains and not vice versa.
Given these variations in costs, and the aforementioned benefits associated with the different BoNT-As, we investigated the budget impact of treating patients with CD in the UK with BoNT-As, taking into account assumptions on evolution of market shares.
Assumptions of linear evolution are not truly appropriate in the analysis of multi-gene family members which are likely to undergo frequent recombination, as the var and sicavar genes are known to do [ 19, 63, 64].
These major inconsistencies observed between the frequency of mutation accumulation and existing natural patterns of molecular variation are leading some to challenge one of the most primary assumptions of molecular evolution; that sequence comparisons of natural molecular variation can accurately represent underlying neutrally evolving mutational processes (Lynch et al. 2008; Denver et al. 2009).
Although standard models of nucleotide evolution violate the assumption of independent evolution of all sites when also applied to paired sites as done by Redmond et al. [ 41], this seems to have little impact on nodes with high support values in the case of the demosponge dataset studied (compare Fig. 1 in [ 41] with our Fig. 5).
The co-evolution of doublets violates the assumption of independent evolution of sites made by most phylogenetic methods [ 7].
The mDPCoA is above all a descriptive method, as it does not rely on any assumptions about models of evolution such as linkage equilibrium or selective neutrality.
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