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The study plans to initially enrol 4800 patients; however, a sample size re-estimation will be performed approximately 1.5 years after study start using baseline assumptions from study enrolments to that point.
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Thus, the health impacts of the air pollution are best characterized using PM2.5 using relative risk assumptions from studies of a mix sources.
The necessary sample size was calculated using assumptions from the study of Gordon-Lipkin [19].
Therefore, once exposed to the insecticide (based on the tier 1 exposure assumptions from this study), the risk of any adverse health effects to the adult female would be negligible.
The model used in the present study carries over all other assumptions from previous studies that do not relate to pre-emptive vaccination.
Thus, further studies are needed in order to confirm the assumptions from previous studies and increase the level of evidence for CRP as a useful marker for detecting inflammation after surgery in dogs.
Our findings do not support the established assumptions from previous studies that the Little Ice Age was responsible for a change in the burning rate, nor that probabilities of burning are spatially homogeneous in mountain landscapes.
The sensitivity analysis used assumptions from different studies and thus further quantified the information gap in Germany regarding ADEs.
Despite large differences in the information and assumptions from different studies and countries, the estimate of AFs remains low at around 3 4% and well below 1% for some countries.
Our initial power calculations were based on assumptions derived from studies where wild-type samples were used as comparator group [23] [25].
The use of local decision impact study data versus assumptions from a validation study in step 1 is one example, particularly when the clinical data underpinning the second step of the analysis is sound.
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