Sample size was determined by using single population proportion formula n = (Zα/2) × P (1 - p)/ d] with the assumption of 50% proportion since no previous study done, at 95% confidence interval, margin of error 5%, 10% none response rate and design effect 2. Finally, the required sample size was 806 head of Households.
In a second part, we focused on a metapopulation context comprising more than two patches and relatively small population sizes, without making the assumption of constant proportion of susceptibles over time.
Under the assumption of similar proportions of abnormalities as that reported during a VCM exposure, 12 14 our sample calculation indicated that we would need 27 participants in each of the exposed and non-exposed groups to find a change in probability of 35% (ie, 40% in exposed vs 5% in non-exposed) for a power of 80% and a two-sided α of 5%.
The sample size was calculated using a single population proportion formula with the assumptions of 50%% proportion (p), since there is no similar study, 95%% confidence level (z), and 5%% margin of error (d).
The sample size was determined based on a double population proportion principle on the assumptions of a proportion of LACM use in Mekelle town (12.3 %) [ 10], a confidence level of 95%%, and a 5%% degree of precision, 80%% power of a test, ratio of exposed to unexposed 1 1 and assuming an odds ratio of 2. We added a 10%% of the calculated sample size to compensate the expected non-response.
The sample size was determined by using single population proportion formula with the assumption of: 50 % proportion, 95%% confidence level and 5%% margin of error.
Sample size was determined with the assumption of single population proportion considering 0.5 previous proportion, 5% margin of error and 95% confidence intervals (CI) and 5% non-response rate and the final sample size was computed to be 400.
IUU catches were estimated as 30% of official landings [15] [17], and a further analysis was performed with additional assumptions of IUU proportion (50%, 100%, 300%, 500% and 1000% of official landings).
To meet the assumptions of normality, proportion variables were arcsine transformed; all other variables were ln transformed.
The baseline assumptions of the proportion of patients who fall into the full, partial, or nonadherent categories are based on the information contained in the only published latent class analysis reporting adherence rates of an antipsychotic medication for patients in the United States [ 62].
We report the total costs under the assumption of an inverted proportion of CIN1 treated (i.e. 63% instead of 37%).
