Exact(7)
Assuming a coefficient of 0.03, a threshold of about 5000 m2 was obtained.
A group size of 30 participants (in the non-CPG and CPG groups combined) gave a power of 0.8 for detecting a 2.4 fold difference in antibody responses between the groups, assuming a coefficient of variation in antibody responses of 1.7 and a significance level of 0.05.
To achieve this, assuming a coefficient of variation of 0.2 to account for clustering, 12 we aimed to retrieve 60 case records per facility.
Assuming a coefficient of variation of 0.25, 80% power, 5% significance, and 20% loss to follow-up, 13 patients from 36 outlets in each arm were required, a total of 468 patients per arm.
Using methods for cluster randomised trials and assuming a coefficient of variation between clusters of 0.2, 80 adults and 114 children per community were required to detect the specified reductions with 80% power at the 5% significance level.
19 We aimed to detect a 50% reduction in the house indices, with a power of 80% and an α error of 0.05, assuming a coefficient of variation (standard deviation divided by the mean) of 0.25 for the clusters' house index.
Similar(52)
We assumed a coefficient of variation between clusters of 0.12.
However, since the (hypothetical) donor organism is unknown and because the signature of the genomic islands could easily show a different statistical behaviour from that of genomic DNA, we will assume a coefficient of -0.5.
Briefly, we assumed: a coefficient of variation of 0.2; prevalence of ICD-10 common mental disorders of 66% among participants who screened positive; follow-up of 75% at 6 months.
If we assume a coefficient of variation of 80%, we would require a sample size of 2×210=420 evaluable patients to reach a power of 90% for the proof of non-inferiority in case of equivalence of the two study arms (one sided α=0.025).
While we are unsure how the local minitubule environment may affect the diffusion coefficient, assuming a diffusion coefficient of a small molecule in the cytoplasm (Milo et al., 2010), it would only take a few milliseconds to travel 1 μm through a minitubule.
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