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As such, this approach assumes alterations in CL between adults and children are solely attributed to differences in organ size (i.e., growth).
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Also, this model assumes significant alterations in the protonation constants of the carboxylic and catechol groups due to intra- and intermolecular interactions (see Table 1).
It can be assumed, that alterations of cell surface sugars change the antigen recognition map of the cells.
In sum, it can be assumed that alterations in emotional experience constitute a mechanism relating neuroticism development to psychopathology.
We assumed that alterations in costimulation mechanisms via B7 proteins might contribute to the lower level of T lymphocyte activation compared to NP women.
Using this network, the authors [ 12] selected a group of genes showing higher connectivity, assuming that alterations in those genes would affect more genes within the network.
It is assumed that alterations in charge distribution in these amino acids may play a role in transition to a secondary structure.
This consideration together with the ubiquitous expression of our genes of interest (TARDBP, C9ORF72, SOD1 or FUS) provided a rationale to assume that alterations directly induced by mutations in these genes might be represented in LCLs.
As it has been demonstrated that activated platelets aggregate at sites of vascular Aβ promoting CAA by inducing platelet thrombus formation (Roher et al. 2009; Gowert et al. 2014), it is tempting to assume serotonin alterations in AD.
In Eukaryotes, changes in the protein isoelectric point (iP) may directly influence the localization and reactions of proteins, and it is reasonable to assume that alterations to the global protein iP may interfere in interactions between proteins and complexes.
Flegr [ 30] suggested that, since cell cytoplasm pH is stratified ranging from 6.4 to 7.2 in Eukaryotes, changes in the protein isoelectric point may directly influence the localization and reactions of proteins, and it is reasonable to assume that alterations to the global protein iP may interfere in interactions between proteins and complexes.
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