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Whereas the ionotropic quick acting component has been assumed to mediate many varieties of motor learning, studies of the contribution of the mGluR-mediated slow component to motor execution are relatively recent [18], [26].
In particular, inferences depend on whether a single pathway involving the SEBs is assumed to mediate the effect of the agent on cancer incidence.
However, in these tumors rapamycin does not function via mechanisms generally assumed to mediate tumor suppression, including inhibition of HIF-1α and indirect suppression of AKT, but does suppress the mTOR target Cyclin D1 [3].
If CTL are assumed to mediate this anti-viral effect via a lytic mechanism then we estimate that CTL killing is responsible for approximately 40% of productively infected cell death, the remaining cell death being attributable to intrinsic, immune (CD8\ T cell, NK cell, B cell) -independent mechanisms.
But the assumption that costs and benefits trade off in an additive fashion is not valid for the survival cost – reproduction benefit tradeoff that is assumed to mediate the evolution of sexually selected signals.
CTLA-4 has an important inhibitory function in T cell regulation, and is assumed to mediate immunosuppressive properties of human Foxp3+ Treg cells [23].
Similar(43)
Quorum sensing (QS) in Gram-negative bacteria is generally assumed to be mediated by N-acyl-homoserine lactone molecules while Gram-positive bacteria make use of signaling peptides.
Leukocyte adhesion is assumed to be mediated by interactions of adhesion molecules on the tips of microvilli with their counterparts on the lower plate.
The interaction between some interactor at a certain level and its environment is assumed to be mediated by "traits" that affect the interactor's expected survival and reproductive success.
Of particular note is its influence on the pulsatile secretion of luteinizing hormone in human females, an effect assumed to be mediated by the hypothalamic nuclei [16].
Chromatin looping seems to play a dominant role both in transcriptional regulation as well as in chromatin organization and has been assumed to be mediated by long-range interactions in many polymer models.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com