Sentence examples for assumed that activation of from inspiring English sources

Currently, some of the TZDs are designed for the treatment of human cancers expressing high levels of PPARγ because it is assumed that activation of PPARγ mediates their anticancer activity.

As we did not observe any further increase after 6 or 12 hours, we assumed that activation of Smad2/3 becomes saturated at this early time point.

We assumed that activation of differentiation in NT2 cells would require substantial epigenetic modulation, especially changes in PcG presence, histone modification patterns and also DNA methylation.

In LSSRM, however, it is assumed that activation (of DA, for instance) occurs coincident with the initiation of the task or other stimulus.

Therefore, it is reasonable to assume that activation of viral box C/D RNA expression and its processing to short regulatory form enables a more rapid decrease in a target mRNA level.

In addition, they assume that activation of the surfactant system is not a universal response to airway inflammation, but rather a specific response to the disturbance of surfactant function by allergen challenges [ 19].

Interestingly, applying the promoter sequence analysis software, that is, TF search, shows that these transcription factors have potential XREs boxes in upstream sequences, albeit at different frequencies, assuming that activation of Ahr may directly/indirectly modulate the commitment of these T cell subsets.

We also assume that activation of mdm2 by p53 has an associated Hill coefficient of 2 (there is a double binding site for p53 at the Mdm2 promotor [ 14]), and that the half-life of Mdm2 is independent of whether it is free or bound to p53 (ref. [ 15] shows the latter is true in the absence of stress).

We assumed that activation and expansion of γδ T cells before co-stimulation with TLR3 agonists, could reveal the effect of TLR3 ligand at the re-stimulation in our system.

It is thus assumed that results obtained following the activation of a zymogen either by gel electrophoresis or by assays that measure the generation of enzymatic activity with chromogenic substrates should be concordant.

One solution is to assume that unit activation consists of pulses emitted at a globally fixed frequency, and pulse trains that are in phase with one another correspond to the same entity (e.g., see Henderson 1994).