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A static percentage (10%) of viruses were assumed resistant to antiviral drugs.
We then analyzed those data using logistic regression, where the response variable was 1 (susceptible) or 0 (assumed resistant).
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There is no reason to assume resistant pathogens on the basis of disease expression.
It has been assumed that resistant populations will remain resistant unless the relevant alleles impose a substantial fitness cost in the absence of pesticide or herbicide.
Thus, it has often been assumed that resistant strains will always be less transmissible than wild-type strains.
It is assumed that resistant mutants with low transmission fitness (δr) emerge during treatment of individuals infected with the wild-type strain.
On the basis of these facts, Vi-positive strain can be assumed more resistant from antimicrobials than Vi-negative strain.
We assumed antibiotic resistant strains would replace sensitive strains, resulting in stable overall prevalence of pneumococcal disease; this assumption is partly supported by several studies in children finding that overall carriage rates of pneumococcus in the nasopharynx remained stable despite serotype replacement with resistant strains after conjugate vaccination [ 19- 21].
Intermediate resistance and inducible resistance were assumed to be resistant.
Isolates positive for inducible clindamycin resistance were assumed to be resistant to lincosamines and macrolides.
The results presented in this study assume that resistant parasites spread to the general host population from a group of hosts representative of, but generally not mixing homogeneously with, the general host population.
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