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The relationship between GlyT1 occupancy (in percent) and dose of SSR504734 was expressed by the equation: Occupancy % = O max × C p C p + K d, where Omax is the assumed maximal occupancy (i.e., 100%), and Cp is the dose at which occupancy becomes 50%.
Due to the nature of the curve-fitting algorithm, for those responses that did not plateau, the response observed at the highest concentration was assumed maximal.
We assumed maximal and minimal AE values of 9,550 cm and 1,120 cm, respectively.
Consequently, our assumed maximal control reference represents a slight underestimate, with a corresponding impact on every effect and effect concentration estimation.
We assumed maximal contamination based on our observation of tumour-cell contamination in 17 of the 22 evaluable unpurged grafts and the fact that more sensitive methods of tumour detection, such as polymerase chain reaction, often reveal the presence of tumour cells after purging (Lode et al, 1997; Leung et al, 1998).
However, even with this high density of equipment the yearly need in 2008-10 of 38,000 PET estimated by the Danish Board of Health in 2006 cannot be met unless the equipment is utilised more efficiently than the assumed maximal production of 1,200 PET/CT per system and year [ 26].
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Further assume maximal such that and for.
Feasibility of the pressure swing batch distillation separation of ternary homoazeotropic mixtures in different single and double column configurations is investigated by assuming maximal separation.
In practice, for values α ∈ (0, α max ), the V function family assumes maximal values in proximity of local concentration of groups of elements of the set.
Statistical analyses like mine help avoid the opposite extreme of assuming maximal flexibility, because they show that network reactions show constrained evolution.
Figure 3 also illustrates that removal of the FAAH-independent clearance from the model (for example, assuming maximal rate of the process equal to zero) resulted in both substantial changes in the shape of the time response curve and a significant increase of more than 10-fold the maximal biomarker concentration.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com