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Results were most sensitive to the population's underlying risk of fracture and breast cancer, assumed efficacy and costs of treatment, and the discount rate.
A secondary objective is to review the need for, and assumed efficacy of, maximum limits for OTA in selected foods that are currently proposed by Health Canada, based on our reevaluation of the Health Canada risk assessment.
In this calculation, we assumed efficacy of a single-dose of measles vaccine to be 90%, and we assumed that the vaccination rate in case-patients with unknown vaccination history was the same as in case patients with known vaccination history [ 8].
At this time, we computed the product of the coverage for that village and the assumed efficacy of the antibiotic in clearing malaria, and assumed that fraction of children were cured; the remaining children stayed infected.
Under the assumed 3 feeding attempts, the sensitivity analysis revealed the model output, particularly the prevalence of fever, is sensitive to the assumed efficacy of the bed net intervention.
However we conducted a sensitivity analysis to test the robustness of model estimates with respect to possible uncertainty on the assumed efficacy of different vector control activities.
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Assuming efficacy of 93% for CDA and 95% for AL, 650 and 325 evaluable patients, respectively, were required using a one-sided hypothesis test at a 2.5% significance level and a 7% non-inferiority margin.
For the reference vaccine initial efficacy 52% after the third dose we assume efficacies for dose 1 and 2 used previously, namely 40 % and 46 respectively [14].
For all other scenarios we assume the protective efficacy to increase linearly with the dose number, so that the efficacy after one dose is one third of the assumed maximum efficacy.
We assumed 60% efficacy of circumcision in reducing heterosexually-acquired HIV over a lifetime, and varied efficacy in sensitivity analyses.
We assumed the efficacy of the quadrivalent HPV vaccine for preventing HPV 6/11/16/18-related cervicalvicancerncer and genital warts was 95.2%, 100%and98.9%9% respectively [28].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com