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The assumed effectiveness for CCM1 indicates that a corresponding strategy would be very effective in reducing the spread of the epidemic, if R0 is moderate or low and if the number of imported cases does not increase rapidly.
No specific data of rotavirus efficacy against moderate cases exist from a country comparable to Somalia; therefore, we assumed effectiveness against moderate cases of rotavirus to be 20% lower than the estimated effectiveness against severe disease [ 33].
Other sensitivity analyses included: [ 1] reducing assumed effectiveness of pneumococcal vaccination on AOM to 6% (reported in the NCKP trial [ 23]) and increasing effectiveness to the 42.7% reported by Zhou et al. [ 32]; [ 2] varying price of the vaccine by ± 10%; [ 3] varying incidence of invasive disease by ± 10%; and [ 4] varying vaccine coverage rates by ± 10percentt.
*Data reflect calculations made for scenario 7 by estimating changes in assumed effectiveness first dose of vaccine among children 6 months–9 years of age.
For example, plausible changes to the assumed effectiveness of BA led to ICER estimates that remained well below the lower NICE threshold of £20 000/QALY gained.
According to Weycker et al., "the greatest uncertainty in our model concerns the assumed effectiveness of vaccination with PCV13 against IPD and (especially) all-cause NBP …".
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Assuming effectiveness within a clinical setting, another further direction might involve a component or dismantling design to help pinpoint the relative contributions of the various features of the device.
Assuming effectiveness, the research team will work with WIC to refine the MIM components.
In all scenarios, the variable with the greatest effect on estimated cost-effectiveness was the assumed treatment effectiveness of rosuvastatin in the initial prevention stage.
We estimate this using the vaccine coverage of 22% in the controls of the case control study of vaccine effectiveness [ 6] and an assumed vaccine effectiveness of 50% [ 28].
Our model of antiviral effectiveness assumed that antiviral effectiveness in reducing infectivity (AVEi) was constant regardless of when antiviral treatment was initiated.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com