Exact(1)
For the 6-month follow-up period, we will therefore, assume hazard rates of 0.001 and 0.0015 for the NRT Rx and varenicline groups, respectively.
Similar(7)
We further assumed hazard ratios of 0.35 for all CD4 at ART initiation categories.
We assumed hazard ratios and odds ratios to approximate the same measure of risk ratios.
For both cohorts, the interim analyses will have a power of 43.3 % if the assumed hazard ratio of 1.563 in the CCA cohort and 1.854 in the GBCA cohort.
With an assumed hazard ratio of 0.5 in the treatment arms and expected frequency of 'recurrent wheeze' of 12% in the control arm, this resulted in a power of 73% for detection of a statistically significant difference with a significance level of 0.05.
To account for both the occurrence and timing of the first RDT-confirmed symptomatic malaria episode with a parasite density >5,000/μL SMRC50000), survival analysis was carried out using PROC LIFETEST in SAS®, assuming hazard ratio remains constant over time, and considering only the number of subjects at risk at that time point of consideration as denominator.
The usual analysis methods based on the logrank test and the Cox proportional hazard model are therefore not appropriate, because they assume constant hazard ratios.
Even though some individual patient analyses suggest the hazard ratio for stroke varies over time [ 64], we assume the hazard is constant; individual patient data are needed to study this question.
Related(1)
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com