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Genevar has two main functionalities in cis-eQTL analysis: (i) identifying eQTLs in genes of interest, and (ii) observing SNP gene associations surrounding SNPs of interest (Fig. 1).
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Rheological measurements show that the dynamic reversible crosslinks consisting of hydrophobic associations surrounded by surfactant micelles are also effective within the covalent network of the hybrid hydrogels.
However, birth weight and head circumference both were increased in association with surrounding greenness; and associations were robust against the choice of the buffer size and the season of data acquisition for surrounding greenness, and were also observed when the analysis was limited to term births.
Associations of surrounding greenness with birth weight and head circumference were also comparable with estimates from the main analysis when models were limited to term births.
Reduced maternal exposure to air pollution could therefore contribute to observed associations between surrounding greenness and birth weight and head circumference.
These studies could not compare associations with surrounding greenness among different regions, climates, or vegetation patterns because both were conducted within single intraurban settings.
We did not have data on use of green spaces by our study participants, an issue that could be relevant to some of the possible mechanisms (e.g., physical activity) underlying our observed associations between surrounding greenness and pregnancy outcomes.
We also conducted a separate analysis of associations with surrounding greenness at work as well as at home using a weighted average of NDVI at both locations for the subset of participants who worked outside of the home, and the results were consistent with our main findings.
There was also an indication for a similar association between surrounding greenness and average personal exposure to NOx, but the association did not attain statistical significance.
In this study, we have probed the association network surrounding each telomere repeat binding factor TRF1, TRF2, and POT1.
In contrast to the high degree of vascularization and loose association with surrounding nonvascular tissue present in other barriers, the blood-labyrinth barrier is a sandwich of epithelial marginal cells and mesodermal basal cells interconnected by TJs.
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