As the number of associations decreased with increasing physical distance, the significance (q-value) of the associations also decreased (Pearson's non-parametric ranked Rho ρ = 0.332, p<0.0001).
Various inverse associations (decreasing risks with increasing exposure) were also observed.
After Bonferroni's correction, the number of significant associations decreased to 606.
These associations decreased by 16% to 17% but remained significant after adjustment for leptin.
The pattern of results persisted after adjustment for covariates, though overall the strength of the associations decreased.
Furthermore, the variance of estimated adaptations and multivariable associations decreased considerably by implementing a weakly informative prior distribution.
After adjustment for study site, the magnitude of the associations decreased, and most CIs included the null value.
Associations decreased after adjusting for age, and in general, further adjustment (model 1 and model 2) provided similar estimates.
In the fully adjusted model, all associations decreased or remained stable when compared with the unadjusted analyses.
