An association with a functional polymorphism with a gene encoding the peptidyl-arginine deiminase enzyme (PADI4), which catalyses citrullination of arginine, has been identified in Japanese populations [ 58, 59].
Thus, the significance of the association may be brought up by still unknown mechanisms or by linkage disequilibrium (LD) with functional polymorphisms.
We report here on the association of FCGR3A-158V/F FCGR3A-158V/Flymorphism with anti-GPI antibody positive status.
Rather, they have an expected association with 'functional' polymorphisms involved in the regulation or the function of the IFNλ3 gene product.
An association of Val66Met functional polymorphism of the BDNF gene, located on chromosome 11p13, with bipolar disorder has been suggested [ 57].
Some recent studies show an association between a functional polymorphism of BDNF gene (Val66Met) and the susceptibility to nicotine dependence and we hypothesized that this polymorphism was associated with smoking in both schizophrenia patients and healthy controls.
However, no study about the association between this functional polymorphism and sepsis susceptibility was reported.
Two studies in sporadic RA showed no association between the T676G polymorphism in the TNF-RII gene and RA severity [ 27, 29], although one report has suggested an association with functional severity [ 28].
In the present study we investigated the expression of CR1 on E and leukocytes in patients with schizophrenia and evaluated the possible association of CR1 C5507G functional polymorphism with this disorder.
The regions surrounding each polymorphism are well conserved with little recombination, therefore, it likely that, if the associations are real, the observed associations are due to linkage disequilibrium with another functional polymorphism in the region.
Moreover, we found an association of this CD45 functional polymorphism in thymuses with the CCR5 Delta 32 mutation (p = 0.00258).
