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After adjustment for rs2394160 in the replication dataset, there is little evidence of association with candidate polymorphisms rs2857766 and rs1233334 in the nearby genes MOG [22], [36] and HLA-G [37] (Table S3).
A few candidate gene studies have examined the association with candidate genes for one disorder in relationship to the other disorder.
Additionally, we tested the feasibility of measuring estradiol and estrone levels in postmenopausal women on AIs and explored their association with candidate genotypes and AAIA.
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On the molecular genetic level, linkage and candidate gene studies have been used for the genetic analysis of PD, and several potential linkage loci and tentative associations with candidate genes have been found [ 7].
We explored different analytic approaches by also including covariates that were associated with (p < .05) outcome scores at baseline and by examining T1-T2-change scores' associations with candidate covariates.
It should be mentioned that, based on the current study, associations with candidate genes can only be treated as an indication and certainly need further research to be validated.
The majority of genetic association studies with candidate migraine genes could not be replicated [23].
For smaller effects (1.3<RR<2.0), association studies with candidate genes seem to be the only way forward.
Genetic approaches ranging from family studies of monogenic traits to association studies with candidate genes, to whole-genome scans in both humans and animals have identified a small number of genes that contribute to the heritability of bone mass.
The genetics of complex phenotypes have been investigated for decades through association studies with candidate genes that, based on pathophysiological considerations, were suspected to be involved in the development of the phenotype [ 34].
Previous association studies with candidate or tag SNPs have reported a number of SNPs in or near the KLK3 gene that appear to be associated with prostate cancer, PSA levels or both (Cramer et al. 2003; 2008; Pal et al. 2007).
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CEO of Professional Science Editing for Scientists @ prosciediting.com