Sentence examples for association thresholds from inspiring English sources

While few associations meet stringent association thresholds, further analysis of the most strongly associated variants has yielded results of interest (Arking et al, 2008; Weiss et al, 2009).

Sensitivity analyses exploring the effect of different endometriosis association thresholds on pathway analyses showed very consistent results for threshold P < 1.0 × 10−2, with the same top three enriched pathways— WNT signalling, Cadherin signalling and Gonadotropin-releasing hormone receptor pathway.

At the time of this study, 1738 GWAS had been conducted for 816 human traits (including human diseases), together reporting 11 533 trait-associated single-nucleotide polymorphisms (SNPs) reaching a suggestive association threshold of P < 1 × 10−5 (see the Web resource of GWAS catalog: http://www.genome.gov/gwastudies).gov/gwastudies

By conducting experiment for several times, we finally set the association threshold as 1.0.

The association threshold of the ED method was 3.82, and six genome regions were significantly correlated with the PSST.

Using the association threshold of 0.9532, six genome regions distributed on chromosomes 5 and 6 that were significantly correlated with the PSST were identified.

The red dotted line shows the association threshold value (0.9532), and the black arrows on the x-axis represent the location of hot-region for PSST.

For the prostate cancer dataset, we chose a chemical signature association threshold of 0.001 (q ≤ 0.01).

The Wilcoxon and t-test p-values were greater (0.136 and 0.274, respectively) using association threshold P ≤ 0.00001 (451 SNPs).

A q-value of 0.10 was used as a significant association threshold in addition to a more permissive threshold of 0.2.

No meaningful pathway analyses could be conducted on the limited number of genes passing association threshold P < 1 × 10−4 (Supplementary Material, Table S18).