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When treated as an effect modifier in stratified analyses, we found a stronger association of hazard for those with longer door-to-balloon times (>90 min), suggesting that the impact of the after-hours construct is even greater when treatment is delayed.
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21 However, we found that the associations of hazard of readmission with prior history of diabetes were consistent (for 1-year readmission and the readmission at each time interval), suggesting that the history of diabetes is, at least in part, as important as case mix and hospitals' performances in the RFS for patients with diabetes.
The association of risk factors with each outcome was tested using Cox proportional hazard regression.
As anticipated, the associations of overweight (hazard ratio 1.92, 95% confidence interval 1.64 to 2.25) and obesity (4.79, 3.96 to 5.80) with incidence of type 2 diabetes were particularly strong.
The authors found an association between higher levels of hazard and low birth weight and intrauterine growth retardation.
In contrast, in their analysis of the Cardiovascular Health Study, Mukamal et al. [ 20] found that the reported consumption of beer, wine and hard liquor did not have a significant association with hazard of hip fracture.
In an unweighted Cox model adjusting for traditional risk factors we observed little association of statins with CVD (hazard ratio (HR) = 0.97, 95% CI: 0.60, 1.59).
There was no evidence of an association (the hazard ratio for an increase of 1 percentage point was 0.99, 95% CI 0.97 1.02, P-value=0.56).
The association of ACR with the hazard of overall mortality was assessed using Cox regression.
The sign and the magnitude of the martingale residual would reflect the association of SNPs on the hazard rate.
To evaluate the effect of adjustment for cardiovascular risk factors on sex differences, we quantified the association of sex with the subdistribution hazard of cardiovascular disease (or the specific first manifestations) and non-cardiovascular death using the method proposed by Fine and Gray.
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