Although structural variation has been previously associated with autism spectrum disorders, this study reports a genome-wide significant association of common variants with susceptibility to this disorder group.
Pawlikowska, L. et al. Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity.
Peng, S. et al. Detecting genetic association of common human facial morphological variation using high density 3d image registration.
Walia GK, Gupta V, Aggarwal A, Asghar M, Dudbridge F, Timpson N, et al. Association of common genetic variants with lipid traits in the Indian population.
David Altshuler and colleagues compare strategies to fine map the association of common variants at 9p21 with type 2 diabetes and myocardial infarction.
The aim of our study was to assess the association of common sequence variants, and selected interactions, with HDL-c plasma levels.
The present study was designed to investigate an association of common -588C/T and -23G/T polymorphisms within glutamate cysteine ligase modifier subunit gene with susceptibility to bronchial asthma.
Tare A, Lane JM, Cade BE, Grant SFA, Chen T-H, T-H, Punjabi NMderdaLauderdale PC, Gharib SA, Gottlieb DS, Scheer FAJL, Redline S, Saxena R. Sleep duration does not mediate or modify association of common genetic variants with type 2 diabetes.
Tare A, Lane JM, Cade BE, Grant SF, Chen TH, Punjabi NM, Lauderdale DS, Zee PC, Gharib SA, Gottlieb DJ, Scheer FA, Redline S, Saxena R. Sleep duration does not mediate or modify association of common genetic variants with type 2 diabetes.
Evidence has come from different study designs, such as nuclear families, twins, multigenerational families, and case-control samples, together examining the broad spectrum of genetic variation including cytogenetic abnormalities, copy number variants, genome-wide association of common variants, and sequencing studies targeting rare and/or de novo variation.
In an attempt to overcome these barriers, the current study utilized GWAS meta-analysis to examine the association of common genetic variation (~8M single-nucleotide polymorphisms (SNP) with minor allele frequency ⩾1%) to general cognitive function in a sample of 35 298 healthy individuals of European ancestry across 24 cohorts in the Cognitive Genomics Consortium (COGENT).
