Association analysis between the genotypic and phenotypic data was performed using Single Marker Regression Analysis.
Since drugs targeting ERK signalling pathway, such as BRAF inhibitors and ERK inhibitors, are single-target compounds rather than multi-target ones, which benefits the association analysis between drug sensitivity and genomic alterations.
Therefore, we conducted association analysis between the FGP and marker genotypes of F2 individuals by conducting single-locus ANOVA, since it is less sensitive to even modest numbers of phenotypic mis-scores (Jeung et al.2007).2007
Instead of inferring genotypes of segregating progenies at the floury locus by using the estimated FGP, we conducted association analysis between the FGP and marker genotypes of F2 individuals by using single-locus ANOVA.
Traditional approaches for mapping quantitative trait loci (QTLs) are based on a direct association analysis between DNA marker genotypes and end-point phenotypes, neglecting the mechanistic processes of how a phenotype is formed biochemically.
The association analysis between single nucleotide polymorphisms (SNPs) and disease or endpoint in genome-wide association studies (GWAS) has been considered as a powerful strategy for investigating genetic susceptibility and for identifying significant biomarkers.
Validation set 1 consisted of an independent association analysis between diagnostic leukemia cell gene expression and germline SNPs from a separate group of 134 patients with newly diagnosed ALL.
In order to statistically compare LD between each of these four populations, an association analysis between haplotypes and population membership was conducted between each of the populations and between each population and all the individuals in other populations.
Validation in set 2 consisted of an independent association analysis between publicly available SNP and gene expression data from the 60 CEU and 60 YRI individuals that constitute the core unrelated members of the HapMap lymphoblastoid cell lines.
For the association analysis between fluid overload and body mass index, Pearson's correlation coefficient was applied.
Therefore, association analysis between haplotypes of TaGW2-6B and grain traits took population structure into account.
