Cells associated with the endpoint are marked with a green "x" Fig. 6 Relation between an image corner and its representation in the 3D Hough space.
These include the size of the treatment response, the inherent variability associated with the endpoint of interest among normal, untreated males, and the number of replicate animals per treatment group.
For multivariate models, all variables associated with the endpoint (P<0.2) were entered, with age and gender forced into the model.
HIV-1 RNA and GSS remained associated with the endpoint when considering only treatment-naïve patients in a sensitivity analysis.
By fitting a multivariable Cox regression, variables independently associated with the endpoint were consistent with those obtained for the subset of treatment-naïve patients (data not shown).
The probability of finding at least one positive association among the 100 tests is virtually 100% even if none of the markers is associated with the endpoint.
When recalculating the Loekito score, 8 we found that urea, creatine, albumin, haemoglobin and white cell count were not significantly associated with the endpoint of 1-day mortality.
However, after multivariate analysis of candidate variables associated with 2-year MACE, those that were significantly associated with the endpoint studied were age (p = 0.007), CRP (p = 0.048) and systolic blood pressure (p = 0.008).
In a multiple Cox regression model, all the variables found to be significantly associated with the endpoint at univariate analysis (ghrelin, obestatin, leptin, metastatic disease and chronic kidney disease) were tested to identify independent predictors.
When recalculating the Asadollahi score, 11 we assigned a score of one each to haemoglobin, platelets and glucose (none of which were significantly associated with the endpoint), three to sodium, four each to age and white cell count and six to urea.
