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In adjusted Cox regression analysis, being female (HR = 2.13, 95% CI = 1.26-3.62, p = 0.005) and being exposed to passive smoking (HR = 2.06, 95% CI = 1.27-3.34, p = 0.003) were associated with the development of asthma while no statistically significant associations were identified for rural residence, being overweight, and other health behaviours.
Oxidative stress can be assessed via 8-isoprostane generation, which is associated with the development of asthma and cardiovascular disease.
Epidemiologic studies suggest that deficiencies of the nutrients selenium; zinc; vitamins A, C, D, and E; and low fruit and vegetable intake may be associated with the development of asthma and allergic disorders.
Jaakkola et al. (1999) suggested that DEHP is associated with the development of asthma in children.
Meta-analyses have shown that some adverse environmental factors could be associated with the development of asthma later in life.
Genetic variations in TLR1, TLR2, TLR4, TLR6 and TLR10 have been associated with the development of asthma [ 40].
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Their results indicated that the severity of atopic status may be associated with the development of classical asthma with wheezing.
Of note, genetic variation in this gene has been previously associated with the development of childhood asthma [ 29, 30] and cytokine secretion at birth [ 31].
10 RSV infection in infancy has also been associated with the development of wheeze and possibly asthma later in later years, with accumulating evidence for causality.
It has been associated with the development of pulmonary inflammatory diseases such as asthma [ 37].
Childhood asthma is strongly associated with the development of atopy and T helper type 2 (Th2 -driven allergic airway inflammaTh2 -drivent allergic8; Holt airwayy, 2012).
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