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However, the application of these regression models for regional mapping over a large geographic areas can be difficult because of challenges associated with the adequate characterization of subsurface soil and groundwater conditions, geotechnical properties, regional topography, and uncertainties associated with the causative seismic loading.
Different ICU populations had similar patterns of mortality associated with the causative anions.
Hayes et al. [ 20] have proposed that the observed higher SNP effects at CSN3 locus might not be due to direct genetic effects, but rather to the fact that the SNP are physically associated with the causative mutation responsible for the observed variation.
If the underlying assumptions of the statistical model were correct, this would lead to only false positives in the final analysis, leading the authors to infer the presence of 658 candidate SNPs associated with the causative differences between the two populations.
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Each subtype is associated with the known causative genes PRRT2, SLC2A1 and PNKD, respectively.
The study provides the first investigation of putative regulatory SNPs around genes showing cis-linkage, and insight into the challenges associated with identifying the causative regulatory variants in such populations through bioinformatic sequence analyses methods.
Our results are however in line with those of Shorr et al., who could not identify clearly any parameter associated with the Candida species causative of candidemia [ 10].
Such elongated contours in the density anomaly are likely to be associated with the orientation of the causative rupture plane inferred from the major axis of the isoseismals.
On the other hand, the result may reflect different risk factors for mastitis: udder conformation may be associated with the physical contamination by the causative bacteria, while the QTL study may localize the genes involved in the immunological control of infection.
It seems that this multifactorial character of BEN aetiology is associated with the multilevel distribution of causative agents within a pathogenetic chain of events.
Future studies will be required to ascertain whether RA, SLE and T1D are associated with the same or different causative variants within the 6q23 region, and whether the locus harbours risk alleles for other auto-immune or inflammatory diseases.
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