It should be mentioned that excessively high concentrations may be undesirable; it has been reported that increased serum adiponectin and HOMA-IR could be associated with an augmented risk for the presence and development of cardiac autonomic neuropathy [ 129].
Moreover, when employing saxagliptin, while the drug was not associated with an augmented risk for ischemic events, it should be pinpointed that the rate of hospitalization for heart failure was significantly increased.
In a group of patients with heart transplants, the presence of coronary endothelial dysfunction at baseline was associated with a significant augmented risk of developing arteriolosclerosis at the 1-year follow-up, as well as atherosclerotic lesions (29).
Clinically, AA intake has been associated with poorer CaP prognosis (Wynder et al, 1994) and an augmented risk of high-grade CaP (Chavarro et al, 2007; Szymanski et al, 2010).
3 4 19 Patients with small-vessel disease have an augmented risk of death after a stroke event.
As previously reported in developed populations, RA was not associated with an augmented prevalence of hypertension in the present investigation [ 34].
Cardiac hypertrophy is an adaptive response to biomechanical overload or extracellular stimuli and it is associated with augmented risk of heart failure and sudden death [ 1- 3].
Low birth weight (LBW, <2500 g) is associated with augmented risk of adult chronic conditions including the following: obesity, cardiovascular disease, type 2 diabetes, and some cancers [ 2, 3].
Interestingly, patient samples displayed lower levels of miR-16 compared with ovarian surface epithelial cells, the decrease being associated with an augmented cancer cell proliferation and clonal growth.
