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The obtained uniqueness and stability conditions associated with a continuum rate formulation of the microscopic equilibrium problem, contain unusual nonlinear contributions arising from crack interface self-contact mechanisms whose significance for an accurate evaluation of macroscopic critical loads at the onset of instability and bifurcation is then investigated in an innovative way.
Cervical incompetence is increasingly recognised as associated with a continuum of complications including second-trimester miscarriage as well as pre-term birth.
We found that increments in the level of FPG were associated with a continuum of increasing risk for diabetes, which is consistent with previous studies (18– 22).
We also found that genes associated with a continuum of methylation change were over-represented in embryonic development/morphogenesis and nervous system development, consistent with previous reports [ 73, 74].
Prenatal exposure to alcohol is associated with a continuum of effects including growth deficits, dysmorphology, and complex patterns of behavioral and cognitive difficulties resulting from central nervous system damage during fetal life [ 54].
Our data significantly expand the current spectrum of pathogenic variants in PRPS1, confirming that they are associated with a continuum disease spectrum, thus stressing the importance of functional studies and detailed clinical investigations for genotype phenotype correlation.
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PLP1 mutations are known to be associated with a broad continuum of neurological phenotypes ranging from connatal PMD with severe hypomyelination to pure X-linked spastic paraplegia type 2 (SPG2) with even normal brain imaging in some cases.
Importantly, this hopelessness-suicidality factor capturing a distinct feature of depression is associated with a higher severity on the latent distress continuum.
In support of preterm delivery and IUGR being defined pathologies along a continuum of poor fetal growth, IUGR has been associated with a higher risk of spontaneous preterm delivery [8], [58].
Depression appears to be present even at the prediabetes stage of the type 2 diabetes (T2DM) continuum with pooled data suggesting that depression in the nondiabetic population is independently associated with a 37 60% increased prospective risk of developing T2DM (6).
The new Fracture Continuum Voxel Approach (FCVA), is a continuum approach partly able to represent fracture as discrete objects; the geometry of each fracture is represented on a regular meshing associated with a heterogeneous field of equivalent flow properties.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com