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Compared with non-industry associated trials, both industry associated trials as well as trials where the sponsorship was unknown were more likely to report lower annual failure rates, showing ORs of 0.32 (CI95% [0.17 0.60]) and 0.37 (CI95% [0.21 0.63]), respectively.
Given the publication age and when controlling for other factors, the annual failure rate for industry associated trials is significantly lower as compared with non-industry associated trials (OR = 0.21).
When controlling for other factors, the probability of annual failure for industry associated trials is significantly lower compared with non-industry associated trials.
Consequently, it may be assumed that our study underestimated the number of industry associated trials.
Interestingly, the multivariate analysis shows that trials where the financial funding source was not reported had an even lower probability of failure than industry associated trials (OR = 0.33).
Given study age, both industry associated (OR = 0.21; CI95% [0.12 0.38]) and unknown funding source trials (OR = 0.33; (CI95% [0.21 0.51]) had a lower annual failure rates compared with non-industry associated trials.
Similar(45)
If a found solution is fitter than its parent, its associated trial count is reset to 0; otherwise, its associated trial count is add by 1.
Journal articles and associated trial summaries failed to describe a substantial proportion of SAEs.
One review author (VB) extracted data from eligible retention trial and associated host trial papers and a second review author (JT) checked the entries.
118 119 Trial location has also been associated with trial outcome, 120 aspects of trial quality (eg, authenticity of randomisation 121), and generalisability.
There are endless frustrations, humiliations, even terrors associated with trials.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com