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In this work, only data associated to studies 1 (Harper or India 7124 variola strains through a combination of aerosol exposure [5 × 108 plaque-forming units (pfu)] and high-titer i.v. inoculation [109 pfu]) and 2 (India 7124 strain via i.v. route alone [109 pfu]) [ 1] were used.
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Within this study, dose limiting toxicities (DLTs) are defined as any grade IV toxicity according to CTCAE Version 4.0 possibly, probably or definitely associated to study treatment during 30 days after completion of therapy.
Primary endpoint to determine the MTD out of the five investigated dose levels is any Grade IV toxicity according to CTCAE Version 4.1, possibly, probably or definitely associated to study treatment and occurring within 3 months after completion of the study treatment.
Primary endpoint to determine the MTD that is chosen out of seven dose levels is any Grade IV toxicity according to CTCAE Version 4.0, possibly, probably or definitely associated to study treatment and occurring during 30 days after completion of the study treatment.
The primary endpoint is the occurrence of a dose limiting toxicity defined as any Grade IV toxicity according to CTCAE Version 4.1, possibly, probably or definitely associated to study treatment and occurring within 3 months after completion of the study treatment.
The primary endpoint is the occurrence of a dose limiting toxicity defined as any Grade IV toxicity according to CTCAE Version 4.0, possibly, probably or definitely associated to study treatment and occurring during 30 days after completion of the study treatment.
Only deep epidemiological studies associated to genetic studies may tell whether this is a valid conjecture or sheer nonsense (Livshits 2005).
The sources and the potential availability of chromium were investigated in ultramafic soils from Niquelândia (Goïas State, Brazil), with chemical extractions associated to mineralogical studies, in order to evaluate its bioavailability and its potential impact on the soil biodiversity.
Genomes associated to population studies are stored and analyzed as 'healthy'; genomes from subjects affected by mitochondriopathies are reported in a separate category and annotated as 'patient'patient
The development of genetic maps for Arachis diploid wild species with A and B genomes associated to phylogenetic studies effectively is a significant advance towards the construction of a transferable reference map for Arachis.
This is very difficult to estimate due to a likely low cell density combined with the difficulties associated to the study of subsurface rock-associated bacteria.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com