Alternatively, even if similar selection goals might have driven to fixation the same variant in all the breeds compared, different SNP alleles might still be associated to it at more distant loci.
Also, this deletion was statistically significantly associated to both recurrence and distant metastases in this patient cohort.
High MIB-1 LI were strongly associated to the development of recurrences/distant metastases as well as with shorter DFS and OS intervals, both in univariate and multivariable analysis.
In secondary analyses, neither expression of p-AKT nor p-S6 was associated with time to distant or CNS recurrence (P ≥ 0.05 for all analyses, data not shown).
Despite the fact that surgical resection and adjuvant therapy can cure well-confined primary tumors, breast cancer mortality rates remain high owing to clinical relapse associated with metastasis to distant organs.
Overall, this genomic analysis supports our IHC findings, in which PTEN expression was associated with time to distant and brain recurrence, basal-like tumors, and the development of BCBM.
In addition, progesterone receptor status (p = 0.0190, HR = 2.7, 95% CI 1.2 - 6.0) was significantly associated with time-to-distant metastasis in this group whereas tumor stage, endocrine treatment, tumor grade, and age at surgery were not.
the breast preservation rate should not have been reported as an endpoint as it was not predetermined by the protocol and, therefore, it is subject to bias no aesthetic outcomes were reported loco-regional recurrences are likely to be associated with distant metastases and an increased risk of death.
In our analyses, tumors located at the head of the pancreas were less likely to be associated with distant metastasis.
Of special interest, four genes (GGH, FAAH, PIR and TAF5L) among the identified 51-gene signature were significantly found to be associated with distant metastases [ 3, 4].
