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Overall sperm quality was as strongly associated with relative testes mass as sperm numbers.
An "overall sperm quality" parameter obtained by principal component analysis was positively and very strongly associated to relative testes mass.
An "overall sperm quality" parameter obtained by principal component analysis (which explained 85% of the variance) was more strongly associated with relative testes mass than any individual quality trait.
Sperm swimming velocity was also significantly associated with relative testes mass, but not with body mass (Table 1, Figure 2B).
Thus, SAFB2−/− mice have increased weight of testes, associated with an increase in Sertoli cell number, likely at least in part owing to altered AR signaling.
Our study has revealed that length variation in the N-terminal region of CatSper1, resulting from an excess of indel substitutions favored by positive selection, is associated to relative testes mass, suggesting that sperm competition is a primary force influencing the structural evolution of this intracellular domain of the CatSper channel.
Using immunostaining of a nearly infertile 32 day-old Pten−/− testis, many UTF1+/PLZF- cells and few UTF1−/PLZF+ cells (Additional file 1: Figure S1A) were observed, indicating that Pten-deletion-induced UTF1 expression might boost SSCs differentiation associated with the testes overgrowth of Pten knockout males.
DOI: http://dx.doi.org/10.7554/eLife.00348.010 10.7554/eLiFigure48.011 Figure 5 figure supplement 3. Genes with TSS-associated testes or liver specific NMIs are over-represented for increased differential expression in the same tissue.
These findings suggest that the cytoprotective effects of chrysin and mirtazapine on rat testes were associated with suppression of oxidative stress and apoptotic tissue damage.
Spermatogenesis that occurs in the seminiferous epithelium of adult mammalian testes is associated with extensive junction restructuring at the Sertoli Sertoli cell, Sertoli germ cell, and Sertoli basement membrane interface.
Higher levels of multiple paternity were associated with larger relative testes size, as was previously shown in rodents [21].
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