Sentence examples for associated silencing of from inspiring English sources
Tanaka K, Imoto I, Inoue J, Kozaki K, Tsuda H, Shimada Y, et al. Frequent methylation- associated silencing of a candidate tumor-suppressor, CRABP1, in esophageal squamous-cell carcinoma.
Interestingly, HNRNPC and DHX9 are indeed tightly functionally associated: silencing of DHX9 seriously disturbed the nuclear distribution of the hnRNP C protein [ 37].
In part, this reflects a role for DNMT3a in methylation and associated silencing of self-renewal genes, including Runx1 and β-catenin (Challen et al., 2012, 2014).
Although the genome undergoes a process of global hypomethylation during tumorigenesis, specific CpG islands become hypermethylated with associated silencing of genes.
Our results raise the possibility that methylation and associated silencing of BRCA1 could represent a germline alteration that underlies some cases of familial breast cancer.
We analyzed the possible DNA methylation-associated silencing of the fourteen selected single-copy genes by bisulfite genomic sequencing of multiple clones using primers located around the transcriptional start site of each candidate gene (Table S4).
89 An miRNA hypermethylation profile characteristic of human metastasis was subsequently identified, which suggested that DNA methylation-associated silencing of tumor suppressor miRNAs contributes to the development of human cancer metastasis.
This methylation-associated silencing of TIMP-3 is tumour-specific, and associated with lack of TIMP-3 protein expression in primary cancers.
In papillary thyroid cancer (PTC), BRAF mutation (and hence activation of the MAPK pathway) was associated with decreased radioiodine avidity [24] [26], which can be explained by BRAF mutation-associated silencing of thyroid iodide-handling genes, such as NIS [18], [27], Tg [27], and TPO [26] [29].
Cancer-associated silencing of PMEPA1 may result in elevated levels of AR and increased AR signaling (Fig. 5A).
Our expression and methylation results are consistent with a lack of significant aberrant, tumour-associated silencing of the gene.
