These data support our hypothesis that both wild-type and dwarf fibroblasts develop age-associated sensitivity to ROT, but ROT mediated the development of this sensitivity is delayed in the dwarf fibroblasts.
Significantly, our studies elucidated a potential mechanism involved in CD26/DPPIV-associated susceptibility to doxorubicin and etoposide-induced G2/M arrest by revealing a correlation between topoisomerase II α activity and protein level and CD26-associated sensitivity to the topoisomerase II inhibitors.
Regulatory focus theory proposes two motivational orientations for personal goal pursuit: (1) promotion, associated with sensitivity to potential gain, and (2) prevention, associated with sensitivity to potential loss.
In a previous study of embryonal carcinoma, high expression of the pluripotency-associated DNA methyltransferase 3B (DNMT3B) was associated with sensitivity to 5-Aza [ 77, 83].
Studies have indicated that amplification of EGFR and overexpression of the EGFR ligands are associated to sensitivity to anti-EGFR mAbs, whereas mutations of BRAF, of PIK3CA and loss of PTEN expression are associated with resistance.
Xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy are three distinct human syndromes associated with sensitivity to ultraviolet radiation.
"Contrary to expectation, presbycusis is also associated with sensitivity to loud noises," Dr. Lalwani said.
KRAS, NRAS, and BRAF mutations are associated with sensitivity to MEK inhibitors, but EGFR mutations are not (Fig. 2c).
Patients with migraine are attacked by disabling headache associated with sensitivity to afferent inputs, including gastrointestinal inputs, light, sound, and head movement [1].
